2010 Fiscal Year Final Research Report
Establishment of objective evaluation of neuropathic pain based on axonal ionic pathophysiology
| Project/Area Number |
21790834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
MISAWA Sonoko Chiba University, 大学院・医学研究院, 助教 (30375753)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 軸索機能検査法 / 軸索Na電流 / 神経原性疼痛 / 糖尿病性末梢神経障害 / Naチャネル阻害薬 |
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| Research Abstract |
Peripheral nerve injury alters function and expression of voltage gated Na^+ channels on the axolemma, leading to ectopic firing and neuropathic pain. We investigated changes in nodal persistent Na^+ currents in human sensory axons using computerized threshold tracking system. Neuropathic pain was significantly associated with increased Na^+ currents and was suppressed by administration of Na^+ channel blocker associated with decreased Na^+ currents. Objective degree of pain could be evaluated by threshold tracking system.
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[Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis : specificity, sensitivity, and a possible prognostic value.2011
Author(s)
Noto Y, Shibuya K, Sato Y, Kanai K, Misawa S, Sawai S, Mori M, Uchiyama T, Isose S, Nasu S, Sekiguchi Y, Fujimaki Y, Kasai T, Tokuda T, Nakagawa M, Kuwabara S.
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Journal Title
Amyotroph Lateral Scler. 12(2)
Pages: 140-143
Peer Reviewed
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[Journal Article] Altered axonal excitability properties in juvenile muscular atrophy of distal upper extremity (Hirayama disease).2011
Author(s)
Sawai S, Misawa S, Kanai K, Isose S, Shibuya K, Noto Y, Fujimaki Y, Sekiguchi Y, Nasu S, Nomura F, Kuwabara S.
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Journal Title
Clin Neurophysiol. 122(1)
Pages: 205-259
Peer Reviewed
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[Journal Article] Multifocal conduction blocksin sarcoid peripheral neuropathy.2010
Author(s)
Sawai S, Misawa S, Kobayashi M, Kanai K, Isose S, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Fujimaki Y, Koga S, Ohtani R, Kuwabara S.
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Journal Title
Intern Med. 49(5)
Pages: 471-474
Peer Reviewed
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[Journal Article] Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain.2010
Author(s)
Isose S, Misawa S, Sakurai K, Kanai K, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Fujimaki Y, Yokote K, Kuwabara S.
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Journal Title
Clin Neurophysiol. 121(5)
Pages: 719-724
Peer Reviewed
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[Journal Article] Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group. Utility of the distal compound muscle action potential duration for diagnosis of demyelinating neuropathies.2009
Author(s)
Isose S, Kuwabara S, Kokubun N, Sato Y, Mori M, Shibuya K, Sekiguchi Y, Nasu S, Fujimaki Y, Noto Y, Sawai S, Kanai K, Hirata K, Misawa S
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Journal Title
J Peripher Nery Syst. 14(3)
Pages: 151-158
Peer Reviewed
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[Journal Article] The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials : multivariate analyses.2009
Author(s)
Fujimaki Y, Kuwabara S, Sato Y, Isose S, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Taniguchi J, Misawa S.
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Journal Title
Clin Neurophysiol. 120(9) 39(1)
Pages: 1683-1686(63-70)
Peer Reviewed
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[Journal Article] Successful combination treatment with bevacizumab, thalidomide and autologous PBSC for severe POEMS syndrome.2009
Author(s)
Ohwada C, Nakaseko C, Sakai S, Takeda Y, Abe D, Takeuchi M, Sakaida E, Masuda S, Shimizu N, Cho R, Nishimura M, Kanai K, Misawa S, Kuwabara S.
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Journal Title
Bone Marrow Transplant. 43(9)
Pages: 739-740
Peer Reviewed
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[Journal Article] Neuromuscular transmission is not impaired in axonal Guillain-Barre syndrome.
Author(s)
Kuwabara S, Kokubun N, Misawa S, Kanai K, Isose S, Shibuya K, Noto Y, Mori M, Sekiguchi Y, Nasu S, Fujimaki Y, Hirata K, Yuki N.
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Journal Title
J Neurol Neurosurg Psychiatry. In press
Peer Reviewed
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