2010 Fiscal Year Final Research Report
PET imaging of brain oxidative stress in patients with Parkinson's disease
Project/Area Number |
21790838
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neurology
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Research Institution | University of Fukui |
Principal Investigator |
IKAWA Masamichi University of Fukui, 医学部附属病院, 助教 (60444212)
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Project Period (FY) |
2009 – 2010
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Keywords | 神経機能画像学 / パーキンソン病 / 酸化ストレス / 神経変性疾患 / PET |
Research Abstract |
[^<62>Cu]ATSM PET imaging demonstrated that striatal oxidative stress was enhanced in patients with Parkinson's disease compared with the controls and was increased with the progression of disease severity. These findings indicated that oxidative stress associates with striatal neurodegeneration in Parkinson's disease.
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[Journal Article] Abnormal myocardial energy-production state in mitochondrial cardiomyopathy and acute response to L-arginine infusion : C-11 acetate kinetics revealed by positron emission tomography.2010
Author(s)
Arakawa K, Kudo T, Ikawa M, Morikawa N, Kawai Y, Sahashi K, Lee JD, Kuriyama M, Miyamori I, Okazawa H, Yoneda M.
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Journal Title
Circulation Journal. 74巻
Pages: 2702-2711
Peer Reviewed
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[Presentation] Cu-ATSM is a novel indicator of intercellular over-reduced states in mitochondrial dysfunction : fundamental evaluation using mitochondrial DNA-less (ρ0) cells and cybrids carrying causal mitochondrial DNA mutation of MELAS syndrome.2010
Author(s)
Kuroda Y, Yoshii Y, Yoneda M, Ikawa M, Kiyono Y, Mori T, Yoshii H, Furukawa T, Asai T, Okazawa H, Fujibayashi Y.
Organizer
7th Annual Meeting of ASMRM and 10th J-mit.
Place of Presentation
福岡
Year and Date
2010-12-16
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