2010 Fiscal Year Final Research Report
The analysis of the transportation of amyloid-β peptide across the blood-brain barrier
| Project/Area Number |
21790841
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SANO Yasuteru Yamaguchi University, 医学部附属病院, 助教 (20379978)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アルツハイマー病 / 血液脳関門 |
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| Research Abstract |
Alzheimer's disease (AD) is the most common cause of dementia. Although several in vivo studies suggest that the blood-brain barrier is compromised in AD brain, the underlying mechanisms remain unclear. In this study, we demonstrated that Aβ42 decreased the expression of claudin-5 and disrupted the tight junction of human brain endothelial cell lines. In addition, we examined whether efflux transporters expressed in the BBB are involved in the transportation of Aβ across the BBB. Our in vitro study suggested that ABCG2 transcytosed Aβ40 out of the brain across the blood-brain barrier.
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[Journal Article] Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function.2010
Author(s)
Sano Y, Shimizu F, Abe M, Maeda T, Kashiwamura Y, Ohtsuki S, Terasaki T, Obinata M, Kajiwara K, Fujii M, Suzuki M, Kanda T.
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Journal Title
J Cell Physiol. 225
Pages: 519-528
Peer Reviewed
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[Journal Article] Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner.2009
Author(s)
Sonobe Y, Takeuchi H, Kataoka K, Li H, Jin S, Mimuro M, Hashizume Y, Sano Y, Kanda T, Mizuno T, Suzumura A.
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Journal Title
J Biol Chem. 284
Pages: 31834-31842
Peer Reviewed
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