2010 Fiscal Year Final Research Report
The characterization of TDP-43 aggregation in Amyotrophic Lateral Sclerosis (ALS)
| Project/Area Number |
21790850
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Keywords | ALS(筋萎縮性側索硬化症) / TDP-43 / caspase-3 / aggresome / stress granule / RNA |
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| Research Abstract |
We identified that caspase-3 generates two 35-kDa and 25-kDa fragments under the apoptotic condition. However, novel caspase-3-independent isoforms of these two variants were also detected under normal conditions. The 35-kDa fragment expression led to the formation of stress granules, while aggresomes were formed in the cytoplasm of cells expressing 35-kDa fragment in the presence of proteasome inhibitors.
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