2010 Fiscal Year Final Research Report
Isolation and analysis of dopamine neurons derived from patient iPS cells
| Project/Area Number |
21790851
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Keywords | 移植・再生医学 / 脳神経疾患 / 細胞・組織 / パーキンソン病 / iPS細胞 |
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| Research Abstract |
Dopamine neurons derived from human iPS cells were investigated. We confirmed that they have Angiotensin receptor-like 1 (Agtrl1) and Interleukin-1 receptor 1 (IL1R1) on the surface of dopamine neurons derived from human iPS cells. During the differentiation from human iPS cells, administration of Apelin or Interleukin-1β (IL-1β), which are the ligands of those surface markers, increased the numbers of dopaminergic neurons. Those neurons showed less vulnerability to toxic 1-methyl-4-phenylpyridinium (MPP+).
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