2010 Fiscal Year Final Research Report
Roles of autonomic nervous system in inter-organ metabolic communication.
| Project/Area Number |
21790859
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMADA Tetsuya Tohoku University, 大学院・医学系研究科, 准教授 (90400374)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 肥満 / 糖尿病 / エネルギー代謝 / 自律神経 |
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| Research Abstract |
The incidence of obesity is rising at epidemic proportions. Several mechanisms underlying the normalization of body weight following involuntary overfeeding are demonstrated ; however, the same excess amount of energy intake resulting from overfeeding does not evoke the same degree of body weight gain. We identified a novel inter-organ communication via neuronal pathway, which suppresses energy expenditure in over-nutritious state. By studying a mouse model, we found out that hepatic glucokinase expression precedes body weight gain due to high fat feeding, and showed that adenovirus-mediated expression of glucokinase in the liver suppressed energy expenditure, resulting in body weight gain. These responses are mediated by a neuronal pathway linking liver, afferent vagus, raphe palllidus, efferent sympathetic nerve, and finally brown adipose tissue, in this order. Furthermore, leptin-induced energy expenditure, primarily observed in overnutritious state, was suppressed by this pathway.
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[Journal Article] Characterization of a novel murine preadipocyte line, AP-18, isolated from subcutaneous tissue : analysis of adipocyte-related gene expressions.2010
Author(s)
Chen C, Takahashi K, Yoshida A, Takizawa Y, Lee Y, Nakui M, Doi H, Takebayashi Y, Fukumoto M, Yamada T T, Katagiri H, Oka Y, Satoh J.
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Journal Title
Cell Biol Int. 34(3)
Pages: 293-299
Peer Reviewed
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[Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.2009
Author(s)
Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Oike Y.
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Journal Title
Cell Metab 10(3)
Pages: 178-188
Peer Reviewed
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[Journal Article] Peginterferon (PEG-IFN) plus ribavirin combination therapy, but neither interferon nor PGE-IFN alone, induced type 1 diabetes in a patient with chronic hepatitis C.2009
Author(s)
Ogihara T, Katagiri H, Yamada T, Kudo H, Imai J, Ishigaki Y, Hinokio Y, Yamagiwa Y, Ueno Y, Shimosegawa T, Oka Y.
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Journal Title
Intern Med 48(16)
Pages: 1387-1390
Peer Reviewed
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