2010 Fiscal Year Final Research Report
The roles of transcription factor FoxO1 in pancreatic β cell proliferation and neogenesis
| Project/Area Number |
21790862
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
KOBAYASHI Masaki Gunma University, 生体調節研究所, 助教 (80373041)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 糖尿病 / 膵臓 / 生理学 |
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| Research Abstract |
In present study, we analyze the characters of pancreas-specific (P-FoxO1-KO) and β cell-specific FoxO1 knockout mice (β-FoxO1-KO) under two different conditions, high fat high sucrose diet and db/db background, to investigate the physiological roles of FoxO1 in the pancreas in vivo. We conclude that FoxO1 functions as a double-edged sword in the pancreas ; FoxO1 essentially inhibits β cell neogenesis but is required for the maintenance of insulin secretion under metabolic stress
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