2011 Fiscal Year Final Research Report
Involvement of SIRT1 activation in improving insulin sensitivity
| Project/Area Number |
21790867
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | University of Toyama |
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Principal Investigator |
KOSHIMIZU Yukiko 富山大学, 大学院・医学薬学研究部(医学), 助教 (30511828)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖尿病 / 脂質 / 老化 |
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| Research Abstract |
SRT1720 treatment suppressed JNK signaling pathway, activated in white adipose tissue of high fat-fed mice. We constructed monocyte/macrophage specific SIRT1 knock out mice and fed high fat diet. In white adipose tissue of high fat-fed monocyte/macrophage specific SIRT1 knock out mice, inflammatory and hypoxia related genes were up-regulated compared with control mice. In conclusion, SIRT1 activation in macrophage was suggested to suppress inflammatory reaction in white adipose tissue of obese model.
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