Development of newly insulin sensitizers via SIRT1

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790871
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Shiga University of Medical Science
• Principal Investigator: YOSHIZAKI Takeshi Shiga University of Medical Science, 医学部, 特任助教 (20510324)
• Project Period (FY): 2009 – 2010
• Keywords: インスリン抵抗性 / 糖尿病 / メタボリック症候群 / SIRT1

Research Abstract

In macrophage and adipocyte, SIRT inhibited inflammatory responses accompany with improvement of insulin sensitivity. SIRT1 activator improved glucose intolerance and insulin sensitivity in obese Zucker Fatty rats. Pharmacological activation of SIRT1 may be a useful anti-inflammatoy therapeutic strategy for treating insulin resistance.

Research Products

• [Journal Article] Olefsky SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. (2010)
  • Author(s): Takeshi Yoshizaki, Simon Schenk, Takeshi Imamura, Jennie L.Babendure, Noriyuki Sonoda, Eun Ju Bae, Da Young Oh, Min Lu, Jill C.Milne, Christoph Westphal, Gautam Bnadyopadhyay, Jerrold M.
  • Journal Title: Am J Physiol Endocrinol Metab Vol298 Pages: E419-E428
  • Peer Reviewed
• [Presentation] インスリン抵抗性におけるSIRT1の治療応用 (2011)
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] 脂肪組織におけるSIRT1のインスリン感受性改善機構にはマクロファージの質の変化も関与する (2010)
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27