2010 Fiscal Year Final Research Report
Role of leptin in pancreatic beta-cell growth and function
| Project/Area Number |
21790878
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Osaka City University |
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Principal Investigator |
MORIOKA Tomoaki Osaka City University, 大学院・医学研究科, 病院講師 (30382154)
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| Research Collaborator |
KULKARNI Rohit N. ハーバード大学, ジョスリン糖尿病センター, 准教授
KENNEDY Robert T. ミシガン大学, 医学部・化学薬理学, 教授
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| Project Period (FY) |
2009 – 2010
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| Keywords | エネルギー・糖代謝異常 / 糖尿病 / シグナル伝達 |
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| Research Abstract |
We found the insulinotropic effects of GLP-1, sulfonylureas and free fatty acid (FFA) are enhanced in mouse pancreatic islets lacking leptin signaling. GLP-1-induced intracellular cAMP-CREB pathway was enhanced in those β-cells. Furthermore, the detrimental effect of chronic FFA treatment on insulin secretion, or "lipotoxicity", was augmented in islets lacking leptin signaling. These results indicate leptin signaling modulates nutritional or therapeutic insulin secretion in pancreatic β-cell.
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