2010 Fiscal Year Final Research Report
Investigation of vascular smooth muscle proliferation by glucose fluctuation
| Project/Area Number |
21790883
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Juntendo University |
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Principal Investigator |
NOMIYAMA Takashi Juntendo University, 医学部, 助教 (10532559)
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| Project Period (FY) |
2009 – 2010
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| Keywords | エネルギー / 糖質代謝異常 |
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| Research Abstract |
Diabetes is a risk factor for atherosclerosis and the prevention of atherosclerosis is very important. We investigated the effects of GLP-1 receptor agonists (Ex-4) on vascular smooth muscle cells. Ex-4 attenuated neointimal formation after wire injury in mice. We demonstrated that the decrease in smooth muscle cell proliferation with Ex-4 may contribute the prevention of atherosclerosis. These unique effects of GLP-1R agonist may help design new therapies for cardiovascular disease in patients with type 2 diabetes.
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