Induction of brown adipogenesis of muscle-derived stem cells

2011 Fiscal Year Final Research Report

• Project/Area Number: 21790884
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Fujita Health University
• Principal Investigator: UEZUMI Akiyoshi 藤田保健衛生大学, 総合医科学研究所, 助教 (60434594)
• Project Period (FY): 2009 – 2011
• Keywords: 褐色脂肪細胞 / 骨格筋 / 間葉系幹細胞

Research Abstract

Generation of new brown adipocytes in adult provides a new therapeutic strategy against obesity. We identified mesenchymal stem cells in adult skeletal muscle and showed that these cells possess high brown adipogenic differentiation potential. Muscle-derived mesenchymal stem cells have an independent developmental origin from a classic brown adipose tissue. We also identified these mesenchymal stem cells in adult human skeletal muscle. Finally, we established efficient gene transduction system that enables highly regulated gene expression in mesenchymal stem cells.

Research Products

• [Journal Article] Fibrosis and adipogenesis originate from common mesenchymal progenitor in skeletal muscle (2011)
  • Author(s): Uezumi A, Ito T, Morikawa D, Shimizu N, Yoneda T, Segawa M, Yamaguchi M, Ogawa R, Milkov M, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Tsuchida K, Yamamoto H, Fukada S
  • Journal Title: J. Cell Sci. Volume: 124(21) Pages: 3654-3664
  • Peer Reviewed
• [Journal Article] Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle (2010)
  • Author(s): Uezumi A, Fukada S, Yamamoto N, Takeda S, Tsuchida K
  • Journal Title: Nat. Cell Biol Volume: 12(2) Pages: 143-152
  • Peer Reviewed
• [Presentation] Roles for nonmyogenic mesenchymal progenitors in skeletal muscle regeneration (2012)
  • Author(s): Uezumi A.
  • Organizer: Keystone Symposia
  • Place of Presentation: California, USA
  • Year and Date: 2012-03-14
• [Presentation] Interaction between non-myogenic mesenchymal progenitors and muscle cells (2011)
  • Author(s): 上住聡芳
  • Organizer: 第34回日本分子生物学会年会ワークショップ
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] 骨格筋の脂肪化や線維化に寄与する間葉系前駆細胞の同定 (2011)
  • Author(s): 上住聡芳
  • Organizer: 第29回日本骨代謝学会学術集会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2011-07-29
• [Presentation] 骨格筋の脂肪変性のメカニズム (2011)
  • Author(s): 上住聡芳
  • Organizer: 第11回抗加齢医学会総会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2011-05-27
• [Presentation] Mesenchymal progenitors distinct from muscle satellite cells contribute to ectopic fat cell formation in skeletal muscle (2011)
  • Author(s): Uezumi A.
  • Organizer: Keystone Symposia
  • Place of Presentation: New Mexico, USA
  • Year and Date: 2011-02-02
• [Presentation] Mesenchymal progenitors distinct from muscle satellite cells contribute to ectopic fat formation in skeletal muscle (2009)
  • Author(s): Uezumi A.
  • Organizer: A joint meeting of Frontier in Myogenesis and Skeletal Muscle Stem and Satellite Cells
  • Place of Presentation: New York, USA
  • Year and Date: 2009-06-01
• [Presentation] Mesenchymal progenitors distinct from muscle satellite cells contribute to ectopic fat formation in skeletal muscle (2009)
  • Author(s): Uezumi A.
  • Organizer: 第7回幹細胞シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-05-16