2010 Fiscal Year Final Research Report
Effect of Thyrotropin-releasing hormone on gene expression in the islet of Langerhans of the pancreas
| Project/Area Number |
21790887
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Gunma University |
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Principal Investigator |
SHIBUSAWA Nobuyuki Gunma University, 医学部, 助教 (90396622)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 糖尿病 / マイクロアレイ / シグナル伝達 |
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| Research Abstract |
Thyrotropin-releasing hormone (TRH) is ubiquitously distributed throughout the brain and other tissues including pancreas. We have reported that the TRH-deficient mice (TRH^<-/->) showed characteristic tertiary hypothyroidism and also hyperglycemia, which was accompanied by impaired insulin secretion in response to glucose. To elucidate the molecular mechanism of TRH effect on insulin secretion, we conducted a microarray study with endocrine islets of mice pancreas. In the microarray analysis, 7827 genes with proper expression levels were detected in islets isolated from both TRH^<-/-> and wild type mice.
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