2010 Fiscal Year Final Research Report
Tissue-specific mechanisms of glucocorticoid-responsive gene expression via HEXIM1
| Project/Area Number |
21790888
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMIZU Noriaki The University of Tokyo, 医科学研究所, 特任研究員 (30396890)
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| Project Period (FY) |
2009 – 2010
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| Keywords | グルココルチコイド / 骨格筋 / ミオパチー / 筋萎縮 / ロコモティブシンドローム / ステロイド副作用 / 分岐鎖アミノ酸 / 栄養 |
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| Research Abstract |
We identified that a mutually exclusive crosstalk between catabolic processes provoked by the adrenal glucocorticoid signal and anabolic processes conducted by nutrition sensing plays a central role in regulating skeletal muscle mass, establishing a molecular basis for developing a therapeutic approach for maintaining muscle mass. Our results suggest that this crosstalk underlies not only pathogenesis of steroid side effects including muscle atrophy but also maintenance of systemic energy homeostasis.
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[Journal Article] Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletalmuscle.2011
Author(s)
Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K,Suematsu M, Morimoto C, Tanaka H.
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Journal Title
Cell Metab. 13(2)
Pages: 170-182
Peer Reviewed
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[Journal Article] Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis.2009
Author(s)
Tokudome S, Sano M, Shinmura K, Matsuhayashi T, Morizane S, Moriyama H, Tamaki K, Hayashida K, Nakanishi H, Yoshikawa N, Shimizu N, Endo J, Katayama T, Murata M, Yuasa S, Kaneda R, Tomita K, Eguchi N, Urada Y, Asano K, Utsunomiya Y, Suzuki T, Taguchi R, Tanaka T, Fukuda K.
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Journal Title
J Clin Invest. 119(6)
Pages: 1477-1488
Peer Reviewed
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[Journal Article] Ligand-based gene expression profiling identifies critical role of glucocorticoid receptor in rat neonatal cardiomyocytes.2009
Author(s)
Yoshikawa N, Nagasaki M, Sano M, Tokudome S, Ueno K, Shimizu N, Imoto S, Miyano S, Suematsu M, Fukuda K, Morimoto C, Tanaka H.
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Journal Title
Am J Physiol Endocrinol Metab. 296(6)
Pages: E1363-E1373
Peer Reviewed
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[Presentation] The rolesof glucocorticoid receptor on cardiac metabolism.2010
Author(s)
Yoshikawa N, Sano M, Tokudome S, Shimizu N, Nagasaki M, Imoto S, Miyano S, Fukuda K, Morimoto C, Tanaka H.
Organizer
14th International Congress of Endocrinology.
Place of Presentation
Kyoto, Japan
Year and Date
2010-03-29
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