2010 Fiscal Year Final Research Report
A study on the mechanisms of ghrelin production and secretion by using a novel ghrelin-producing cell line.
| Project/Area Number |
21790891
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
IWAKURA Hiroshi Kyoto University, 医学研究科, 助教 (20378615)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 内分泌学 |
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| Research Abstract |
In this study, we developed a ghrelin producing cell line MGN3-1, which secretes high amount of ghrelin with physiological acyl-modification and maturation under the physiological regulation, making this cell line one of the best tools to study the mechanisms of ghrelin production and secretion in vitro. Further, we examined the effects of peptide hormones and neurotransmitters on ghrelin secretion from MGN3-1 cells and found that oxytocin, epinephrine and dopamine significantly stimulated ghrelin secretion from MGN3-1 cells in vitro.
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[Journal Article] Molecular characterization of tumors from a transgenic mouse adrenal tumor model : comparison with human pheochromocytoma.2010
Author(s)
Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, Nakao K, Maitani Y.
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Journal Title
Int J Oncol. 37(3)
Pages: 695-705
Peer Reviewed
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[Journal Article] Establishment of a novel ghrelin-producing cell line.2010
Author(s)
Iwakura H, Li Y, Ariyasu H, Hosoda H, Kanamoto N, Bando M, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Endocrinology. 151(6)
Pages: 2940-2945
Peer Reviewed
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[Journal Article] A postweaning reduction in circulating ghrelin temporarily alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does not affect somatic growth.2010
Author(s)
Ariyasu H, Iwakura H, Yamada G, Kanamoto N, Bando M, Kohno K, Sato T, Kojima M, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Endocrinology. 151(4)
Pages: 1743-1750
Peer Reviewed
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[Journal Article] A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.2009
Author(s)
Iwakura H, Ariyasu H, Li Y, Kanamoto N, Bando M, Yamada G, Hosoda H, Hosoda K, Shimatsu A, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Am J Physiol Endocrinol Metab. 297(3)
Pages: 802-811
Peer Reviewed
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