2010 Fiscal Year Final Research Report
Elucidation of molecular mechanisms of the leptin resistance
| Project/Area Number |
21790892
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
KUSAKABE Toru Kyoto University, 医学研究科, 助教 (60452356)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | レプチン / 糖尿病 / メタボリックシンドローム / 肥満 / アミリン |
|---|
| Research Abstract |
Leptin (L)/amylin (A) co-administration significantly reduced food intake and body weight in leptin-resistant diet-induced obesity mice, while administration of L or A alone had no effects. L/A co-administration enhanced insulin sensitivity associated with decreased tissue triglyceride content and increased α2 AMP-activated protein kinase (AMPK) activity in skeletal muscle. This study demonstrates the beneficial effect of L/A co-administration on glucose and lipid metabolism in DIO mice, indicating the possible clinical usefulness of L/A co-administration as a new anti-diabetic treatment in obesity-associated diabetes.
|
