2010 Fiscal Year Final Research Report
The Analysis of Physiological Roles of circulating ghrelin
| Project/Area Number |
21790893
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
ARIYASU Hiroyuki Kyoto University, 医学研究科, 助教 (50378650)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 成長ホルモン / グレリン |
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| Research Abstract |
In this study, we generated a transgenic mouse that expresses human diphtheria toxin (DT) receptor cDNA in ghrelin-secretion cells (GPDTR-Tg mice). Administration of DT to this mouse ablates ghrelin-secretion cells in a controlled manner. Four days after injection of DT into GPDTR-Tg mice, ghrelin-secreting cells were ablated, and plasma levels of ghrelin were markedly decreased. Daily food intake of these animals, however, was not affected. Three-week-old GPDTR-Tg mice were then treated with DT twice a week for five weeks. Although plasma ghrelin levels were reduced, GPDTR-Tg mice did not display any decreases in serum GH or IGF-1 levels or any growth retardation. Our results strongly suggest that circulating ghrelin does not play a crucial role in either feeding behavior or somatic growth.
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[Journal Article] Establishment of a novel ghrelin-producing cell line.2010
Author(s)
Iwakura H, Li Y, Ariyasu H, Hosoda H, Kanamoto N, Bando M, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Endocrinology. 151
Pages: 2940-2945
Peer Reviewed
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[Journal Article] A postweaning reduction in circulating ghrelin temporarily alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does not affect somatic growth.2010
Author(s)
Ariyasu H, Iwakura H, Yamada G, Kanamoto N, Bando M, Kohno K, Sato T, Kojima M, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Endocrinology. 151
Pages: 1743-1750
Peer Reviewed
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[Journal Article] A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.2009
Author(s)
Iwakura H, Ariyasu H, Li Y, Kanamoto N, Bando M, Yamada G, Hosoda H, Hosoda K, Shimatsu A, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Am J Physiol Endocrinol Metab. 297
Pages: 802-811
Peer Reviewed
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