2010 Fiscal Year Final Research Report
Significance of vascular hormones in cellular metabolism and the progression of metabolic syndrome and aging
| Project/Area Number |
21790896
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
MITSUISHI Masanori 慶應義塾大学, 医学部, 大学院生
MURAKI Ayako 慶應義塾大学, 医学部, 助教
TAMAKI Masanori 慶應義塾大学, 医学部, 助教
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| Project Period (FY) |
2009 – 2010
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| Keywords | 内分泌学 / メタボリックシンドローム / 血管ホルモン / エネルギー代謝 / ミトコンドリア |
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| Research Abstract |
Recent clinical studies have indicated that dysregulation of vascular hormones would cause metabolic diseases. The present study demonstrated that natriuretic peptides and angiotensin II could modulate oxygen consumption by regulating muscle mitochondria. The findings suggest significant roles for vascular hormones as modulators of both oxygen supply and consumption, which are essential for the progression of metabolic syndrome and aging.
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[Journal Article] Natriuretic peptides/cGMP/cGMP dependent-protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity.2009
Author(s)
Miyashita K, Itoh H, Tsujimoto H, Tamura N, Fukunaga Y, Sone M, Yamahara K, Taura D, Inuzuka M, Sonoyama T, Nakao K.
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Journal Title
Diabetes. 58
Pages: 2880-2892
Peer Reviewed
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