2010 Fiscal Year Final Research Report
The role of Notch signaling in differentiation of human mast cells
| Project/Area Number |
21790905
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SAKATA Mamiko University of Tsukuba, 大学院・人間総合科学研究科, 講師 (80451805)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Notchシグナル / 臍帯血 / Delta1-Fc / Hes-1 / レトロウイルス |
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| Research Abstract |
We tried to clarify the role of Notch signaling in the differentiation of human mast cells. Hematopoietic stem cells and progenitors, purified from human cord blood cells, were stimulated by plate-coated Notch ligands, or retroviral transduction of Hes-1. Notch - ligand stimulation did not induce mast cell differentiation. We succeeded in retroviral transduction of Notch signaling molecules, but the effect on differentiation of mast cells were still under the observation.
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[Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.2011
Author(s)
Sakata-Yanagimoto, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, chiba S
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Journal Title
Blood. 117(1)
Pages: 128-134
Peer Reviewed
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[Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia.2010
Author(s)
Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S
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Journal Title
Blood. 115(14)
Pages: 2872-2881
Peer Reviewed
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[Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.2009
Author(s)
Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S
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Journal Title
Nature. 460(7257)
Pages: 904-908
Peer Reviewed
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[Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma.2009
Author(s)
Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S
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Journal Title
Cancer Sci. 100(5)
Pages: 920-926
Peer Reviewed
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[Journal Article] Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15.2009
Author(s)
Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S
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Journal Title
Immunol. 182(10)
Pages: 6168-6178
Peer Reviewed
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