2010 Fiscal Year Final Research Report

Role of the integrin-mediated adapter protein in leukemia

Research Project

Project/Area Number	21790908
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Hematology
Research Institution	The University of Tokyo
Principal Investigator	SEO Sachiko The University of Tokyo, 医学部附属病院, 助教 (60401121)
Project Period (FY)	2009 – 2010
Keywords	血液内科学
Research Abstract	We detected the significant infiltration of neutrophils to several tissues in Cas-L-deficient p210Bcr-Abl transgenic mice. Cas-L-deficient neutrophils showed the activated migration and the decreased adhesion ability. Moreover, in homing assay, bone marrow cells from Cas-L-deficient mice were detected in the spleen more than cells from wild-type mice. In proliferation assays and colony assays, there are no differences between Bcr-ABl positive cells and Cas-L-deficient Bcr-Abl positive cells Therefore, the aberrant cell motility was considered to be the reason of extreme neutrophil infiltration in Cas-L-deficient p210Bcr-Abl transgenic mice.