2010 Fiscal Year Final Research Report
Molecular Pathogenesis of Primary Myelofibrosis Mouse
| Project/Area Number |
21790909
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KANEKO Shin The University of Tokyo, 医科学研究所, 助教 (40361331)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 血液腫瘍学 / 癌幹細胞生物学 / 骨髄増殖性腫瘍 / 原発性骨髄線維症 / 造血幹細胞 / 疾患モデル動物 / STAT5A |
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| Research Abstract |
We have developed a model mouse of primary myelofibrosis using genetically modified hematopoietic stem cell transplantation. Progression manner and molecular pathogenesis of bone marrow fibrosis in the mouse have closely resembled to those of the human disease. Using the mouse model, we have demonstrated that normal HSCs also can be affected to lose stem cell potentials in fibrotic marrow. The newly established mouse model would be useful for developing new molecular therapies against primary myelofibrosis.
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