2010 Fiscal Year Final Research Report
Analysis of TNFAIP3 gene function in lymphomagenesis
| Project/Area Number |
21790929
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
HONMA Keiichiro 愛知県がんセンター(研究所), 遺伝子医療研究部, 主任研究員 (20505945)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 非ホジキンリンパ腫 / NF-κB / TNFAIP3 |
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| Research Abstract |
Malignant lymphoma possess histologic and genetic diversity, hence understanding the mechanisms of each cases is important for improving their prognosis. In our present study, we analyzed several subsets of non-Hodgkin lymphomas and found that; (1) TNFAIP3/A20 gene is frequently altered in B-cell lymphoma with NF-kB activation. (2) TNFAIP3 may be involved in lymphomagenesis through inhibiting NF-kB. (3) Our study provides a novel insight into molecular mechanisms leading to lymphoma and that specific targeting of NF-kB pathways may be advantageous for treatment.
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