2010 Fiscal Year Final Research Report
Identification of molecular basis of acute-and lymphoma-type adult T-cell leukemia/lymphoma
| Project/Area Number |
21790930
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
NAKAGAWA Masao 愛知県がんセンター(研究所), 遺伝子医療研究部, 主任研究員 (80435859)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 成人T細胞性白血病 / リンパ腫 / アレイCGH / 遺伝子発現解析 |
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| Research Abstract |
Acute-type adult T-cell leukemia/lymphoma (ATLL) cases frequently have lymph node lesions. I performed detailed genomic analysis and clarified; 1) a part of such cases had genomic alterations similar to those frequently found in lymphoma-type ATLL, 2) multiple subclones with various additional genomic alterations were frequently found in a lymph node of individual cases and a selected subclone among the lymph node subclones appeared in peripheral blood. These new findings indicate that a part of acute-type ATLL cases should be categorized as lymphoma-type ATLL with leukemic change.
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