2010 Fiscal Year Final Research Report
Roles of interleukin-5 receptors on eosinophilic differentiation
| Project/Area Number |
21790933
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Ibaraki University |
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Principal Investigator |
ISHIHARA Kenji Ibaraki University, 教育学部, 准教授 (00312596)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 好酸球 / アレルギー / 分化 |
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| Research Abstract |
Chronic allergic inflammation including bronchial asthma and atopic dermatitis is difficult to treat and the number of patients suffering from such diseases is increasing, probably reflecting environmental changes to life style. Eosinophils are one of the cells that play a critical role in the pathogenesis of allergic diseases. In bronchial asthma, eosinophils increase in number in bone marrow and peripheral blood, and accumulate at inflammatory sites in response to various kinds of cytokines and chemical mediators. Studies have demonstrated the mechanism by which eosinophils prolong their survival, infiltrate inflammatory sites and release granule proteins. However, the mechanism behind the differentiation of stem cells such as CD34^+ cells into mature eosinophils has not been clarified. Clarification of this mechanism is important if one is to understand the generation and maturation of white blood cells, especially myeloid lineages, and may contribute to the development of novel medications for allergic inflammation. Inhibition of the differentiation toward the eosinophil lineage might be useful for the control of allergic inflammation as a preventive measure. In this study, two novel receptors for IL-5R are identified, and named as variant 7 and variant 8.
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[Journal Article] Salicylate restores transport function and anion exchanger activity of missense pendrin mutations.2010
Author(s)
Ishihara K, Okuyama S, Kumano S, Iida K, Hamana H, Murakoshi M, Kobayashi T, Usami S, Ikeda K, Haga Y, Tsumoto K, Nakamura H, Hirasawa N, Wada H.
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Journal Title
Hear Res. 270
Pages: 110-118
Peer Reviewed
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