2010 Fiscal Year Final Research Report
Analysis of cytokine IL-17B and IL-17C in autoimmune diseases
| Project/Area Number |
21790941
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKAMOTO Akiko The University of Tokyo, 医学部附属病院, 助教 (40431861)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 膠原病学 |
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| Research Abstract |
IL-17, a T cell-derived proinflammatory cytokine, contributes to the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). IL-17B and IL-17C belong to the IL-17 family. In our previous study, IL-17B is expressed in the cartilage and monocytes. IL-17C is expressed CD4^+Tcells, dendritic cells (DCs) and macrophages at the inflammatory site. IL-17B and IL-17C exacerbate and maintain inflammation in cooperate with Th17 cells or by themselves. In this study, IL-17B and IL-17C are expressed in the spleen (splenic DCs and macrophages) and kidney of lupus-prone NZB/W F_1 mice with nephritis. To examine the proinflammatory effects of IL-17B and IL-17C in vivo, adoptive transfer of IL-17B and IL-17C transduced CD4^+Tcells into NZB/WF1 is under examination. Assessments of modulation of phagocytosis and autoantigen-presentation capacity by IL-17B and IL-17C are in progress. Increase in IL-17B and IL-17C expression was not observed in PBMC from patients with SLE.
These ongoing experiments would clarify the pathogenic role of IL-17B and IL-17C in autoimmune disease.
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Research Products
(8 results)
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[Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.2010
Author(s)
Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K.
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Journal Title
Arthritis Rheum. 62(2)
Pages: 574-579
Peer Reviewed
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