Role of IL-25 in contact hypersensitivity

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790942
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAE Susumu The University of Tokyo, 医科学研究所, 特任准教授 (60450409)
• Project Period (FY): 2009 – 2010
• Keywords: アレルギー学

Research Abstract

We generated IL-25-deficient mice to elucidate the role of IL-25 in the pathogenesis of contact hypersensitivity. The development of contact hypersensitivity was significantly suppressed in IL-25-deficient mice, suggesting that the neutralization of IL-25 may provide a potential target for therapeutic treatment for contact hypersensitivity.

Research Products

• [Journal Article] Functional specialization of interleukin-17 family members. (2011)
  • Author(s): Iwakura, Y., Ishigame, H., Saijo, S., Nakae, S.
  • Journal Title: Immunity. 34(2) Pages: 149-162
  • Peer Reviewed
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • Author(s): Oboki, K., Ohno, T., Kajiwara, K., Arae, K., Morita, H., Ishii, A., Nambu, A., Abe, T., Kiyonari, H., Sudo, K., Okumura, K., Saito, H., Nakae, S.
  • Journal Title: Proc Natl Acad Sci USA. 107(43) Pages: 18581-18586
  • Peer Reviewed
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. (2010)
  • Author(s): Ishii, A., Oboki, K., Nambu, A., Morita, H., Ohno, T., Kajiwara, N., Arae, K., Sudo, H., Okumura, K., Saito, H., Nakae, S.
  • Journal Title: Allergol Int. 59(4) Pages: 399-408
  • Peer Reviewed
• [Journal Article] Amphiregulin is dispensable for induction of contact hypersensitivity. (2010)
  • Author(s): Yagami, A., Kajiwara, N., Oboki, O., Ohno, N., Morita, H., Sunnarborg, S.W., Okumura, K., Ogawa, H., Saito, H., Nakae, S.
  • Journal Title: Allergol Int. 59(3) Pages: 277-284
  • Peer Reviewed
• [Journal Article] Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction, but not the immediate-type reaction. (2009)
  • Author(s): Nishida, K., Hasegawa, A, Nakae, S., Oboki, K., Saito, H., Yamasaki, S., Hirano,T.
  • Journal Title: J Exp Med. 206(6) Pages: 1351-1364
  • Peer Reviewed
• [Book] Th17 cells in health and disease(ed.S.Jiang)(The roles of IL-17A and IL-17F in mucosal infection and allergy.)New York, NY (2011)
  • Author(s): Ishigame, H., Nakae, S., Iwakura, Y.
  • Publisher: Springer Science+Buisiness Media, LLC