2010 Fiscal Year Final Research Report
Physiological function of PAD4, a rheumatoid arthritis-related protein, and its molecular mechanisms.
| Project/Area Number |
21790943
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKASHIMA Katsuhiko The University of Tokyo, 大学院・医学系研究科, 助教 (90528035)
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| Project Period (FY) |
2009 – 2010
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| Keywords | リウマチ学 / エピジェネティクス / シトルリン化 |
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| Research Abstract |
PAD4 was predominantly expressed in HSC while less in the progenitor cells. Moreover, frequency of HSC in PAD4-deficient mice is higher than that in wild-type mice. Furthermore, the expression levels of some genes related to the cell proliferation were changed in PAD4-deficient HSC compared to wild-type HSC. These results suggested that PAD4 might maintain HSC proliferation in bone marrow by regulation of the gene expression mediated by histone citrullination.
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[Journal Article] Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.2010
Author(s)
Jun Kurokawa, Satoko Arai, Katsuhiko Nakashima, Hiromichi Nagano, Akemi Nishijima, Keishi Miyata, Rui Ose, Mayumi Mori, Naoto Kubota, Takashi Kadowaki, Yuichi Oike, Hisashi Koga, Maria Febbraio, Toshihiko Iwanaga, Toru Miyazaki.
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Journal Title
Cell Metabolism 11
Pages: 479-492
Peer Reviewed
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[Journal Article] The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.2010
Author(s)
Nobuya Kurabe, Mayumi Mori, Jun Kurokawa, Kaori Taniguchi, Hisatoshi Aoyama, Kazuhiro Atsuda, Akemi Nishijima, Nariaki Odawara, Saori Harada, Katsuhiko Nakashima, Satoko Arai, Toru Miyazaki.
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Journal Title
Biochem.Biophys.Res.Commun. 391
Pages: 1708-1713
Peer Reviewed
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