2010 Fiscal Year Final Research Report
Function analysis of autoantigens in human mature osteoclast from rheumatoid arthritis patient under anti-rheumatic drugs.
| Project/Area Number |
21790946
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyoto University |
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Principal Investigator |
NOJIMA Takaki Kyoto University, 医学研究科, 助教 (30327514)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 破骨細胞 / 自己抗原 / 関節リウマチ |
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| Research Abstract |
In osteoclastgenesis system using human peripheral-blood mononuclear cells, we found that calpastatin was cut off and calpain revitalization was elevated from 3 day to 6 day. The protein level changes of calpain 1 and calpain 2 were not detected in our osteoclastgenesis system. Cell permeable calpastatin down-regulated the osteoclastgenesis and the bone absorptivity of human osteoclast. After 15 minutes TNFα (100ng/ml) stimulation, calpain revitalization elevated in human osteoclast.
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[Journal Article] Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset : a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.2010
Author(s)
Ohmura K, Terao C, Maruya E, Katayama M, Matoba K, Shimada K, Murasawa A, Honjo S, Takasugi K, Tohma S, Matsuo K, Tajima K, Yukawa N, Kawabata D, Nojima T, Fujii T, Yamada R, Saji H, Matsuda F, Mimori T.
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Journal Title
Rheumatology (Oxford) 49(12)
Pages: 2298-2304
Peer Reviewed
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[Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010
Author(s)
Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T.
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Journal Title
Arthritis Rheum. 62(12)
Pages: 3730-3740
Peer Reviewed
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[Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.2010
Author(s)
Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T.
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Journal Title
Rheumatology (Oxford) 49(3)
Pages: 433-340
Peer Reviewed
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[Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009
Author(s)
Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T.
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Journal Title
Arthritis Rheum. 60(8)
Pages: 2294-2303
Peer Reviewed
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