2010 Fiscal Year Final Research Report
Regeneration of joint structure by adipogenesis induction of fibroblatst synovial cell in rheumatoid arthritis.
| Project/Area Number |
21790949
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nagasaki University |
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Principal Investigator |
YAMASAKI Satoshi Nagasaki University, 医歯(薬)学総合研究科, 助教 (30367388)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 関節リウマチ / 滑膜細胞 / 脂肪分化 / RNA regulon / iPS |
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| Research Abstract |
Adipogenesis is clearly inhibited by various inflammatory cytokines in both MSC and FLS. The production of IL-6 is inhibited after adipogenesis in both MSC and FLS. Adipogenesis of MSC disrupt the actin structure, which leads to the less migration ability of the cell. Our results indicate that undifferentiated and proliferating MSC in "bone edema", a recently recognized as inflammatory bone marrow lesion in early stage of rheumatoid arthritis, contribute to the progression of the disease, therefore, the adipogenic induction of MSC and FLS can regenerate a favorable joint environment for maintaining auricular structure.
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[Journal Article] 関節リウマチの生物学的製剤投与中に発症した結核感染3症例2010
Author(s)
山崎聡士, 藤川敬太, 荒牧俊幸, 岩本直樹, 川尻真也, 玉井慎美, 中村英樹, 井田弘明, 川上純, 江口勝美, 折口智樹
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Journal Title
九州リウマチ 30巻1号
Pages: 43-48
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