2010 Fiscal Year Final Research Report
Analysis of the epitope and neutralizing capacity of human monoclonal antibodies induced by hepatitis B vaccine
| Project/Area Number |
21790958
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | University of Toyama |
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Principal Investigator |
TAJIRI Kazuto University of Toyama, 附属病院, 助教 (30512165)
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| Project Period (FY) |
2009 – 2010
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| Keywords | B型肝炎ウイルス / 中和抗体 / Small-HBsAg / 抗体療法 / 細胞マイクロアレイシステム |
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| Research Abstract |
We analyzed using monoclonal antibodies for neutralizing HBV, which were obtained by cell-microarray system. Epitope analysis showed that extracellular loop lesion of HBs-Ag has the antigenesity and concerns HBV-neutralization. Combination of the antibodies showed the neutralizing capacity against various genotype of HBV including G145R which is known for the escape mutant. These findings imply that HBV-vaccination is useful for the prevention of HBV-infection with various genotype or mutant HBV. Furthermore, the possibilities of antibody treatment using monoclonal antibodies or their combination for HBV-infection may be suggested.
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