Analysis of the pathogenesis of the IgA nephropathy by the interaction of the innate and acquired immunity in post-viral infection

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790964
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Infectious disease medicine
• Research Institution: Fukuoka University
• Principal Investigator: MIYAKE Katsuhisa Fukuoka University, 医学部, 講師 (50448411)
• Project Period (FY): 2009 – 2010
• Keywords: 自然免疫 / 獲得免疫

Research Abstract

IgA nephropathy (IgAN) in early stage is an asymptomatic kidney disease detected by chance proteinuria and/or hematuria. In this study, we analyzed mRNA expressions of toll like receptors (TLRs) and inflammatory cytokines in the renal biopsy tissues from IgAN in early stage, ANCA-related nephritis and membranous nephropathy patients. As a result the expressions of transcripts for TLR9 and IFNα in IgAN in early stage were significantly higher than those for others. These results suggested that the innate immunity may play a central role for development of IgAN in the early stage. Therefore TLR 9 signal and IFNα will be new candidates for new treatment for IgAN.

Research Products

• [Journal Article] Improvement of dyslipidemia in OLETF rats by the prostaglandin I(2) analog beraprost sodium. (2010)
  • Author(s): Watanabe M, Nakashima H, Ito K, Miyake K, Saito T.
  • Journal Title: Prostaglandins Other Lipid Mediat. 93 Pages: 14-19
  • Peer Reviewed
• [Journal Article] An amplification of IL-10 and TGF-beta in patients with IgG4-related tubulointerstitial nephritis. (2010)
  • Author(s): Nakashima H, Miyake K, Moriyama M, Tanaka A, Watanabe M, Abe Y, Sato H, Nakamura S, Saito T.
  • Journal Title: Clin Nephrol. 73(5) Pages: 385-391
  • Peer Reviewed
• [Journal Article] Lipoprotein glomerulopathy induced by ApoE-Sendai is different from glomerular lesions in aged apoE-deficient mice. (2009)
  • Author(s): Ishimura A, Watanabe M, Nakashima H, Ito K, Miyake K, Mochizuki S, Ishigaki Y, Saito T.
  • Journal Title: Clin Exp Nephrol. 13(5) Pages: 430-437
  • Peer Reviewed
• [Journal Article] Amelioration of diabetic nephropathy in OLETF rats by prostaglandin I(2) analog, beraprost sodium. (2009)
  • Author(s): Watanabe M, Nakashima H, Mochizuki S, Abe Y, Ishimura A, Ito K, Fukushima T, Miyake K, Ogahara S, Saito T.
  • Journal Title: Am J Nephrol. (1) Pages: 1-11
  • Peer Reviewed
• [Journal Article] The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation. (2009)
  • Author(s): Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T.
  • Journal Title: J Biol Chem. 284(8) Pages: 5050-5055
  • Peer Reviewed
• [Journal Article] Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. (2009)
  • Author(s): Igawa T, Nakashima H, Sadanaga A, Masutani K, Miyake K, Shimizu S, Takeda A, Hamano S, Yoshida H.
  • Journal Title: Mod Rheumatol. 19(1) Pages: 33-41
  • Peer Reviewed
• [Presentation] Adalimumabにより,重症血小板減少を発症した関節リウマチの一例 (2011)
  • Author(s): 三宅勝久, 前山彰, 城島宏, 斉藤喬雄, 中島衡
  • Organizer: 第41回九州リウマチ学会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-03-19
• [Presentation] 難治性中枢神経性ループスに対し血漿二重膜濾過法(DFPP)を施行し病勢をコントロールし得た一例 (2010)
  • Author(s): 三宅勝久, 中島裕子, 安野哲彦, 安部泰弘, 斉藤喬雄, 中島衡
  • Organizer: 第40回九州リウマチ学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-09-05
• [Presentation] 高ガンマグロブリン血症を呈した間質性腎炎の2例 (2010)
  • Author(s): 三宅勝久, 中島衡, 城島宏, 斉藤喬雄
  • Organizer: 第39回九州リウマチ学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-07