2010 Fiscal Year Final Research Report
Genome-wide analysis of pathogenesis of congenital anomaly syndromes and clinical applications
| Project/Area Number |
21790970
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MOTOMURA Ai The University of Tokyo, 医学部附属病院, 助教 (40511465)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 先天性奇形症候群 / Noonan症候群 / 結節性硬化症 / SNP array / 卵巣がん / Sotos症候群 / 肝芽腫 |
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| Research Abstract |
Although congenital anomaly syndromes (CAS) often complicate malignant tumors, pathogenesis of CAS and these tumors are not fully understood. Thus, to investigate molecular pathogenesis of CAS and complicated tumors, we performed genome-wide copy number analysis of hepatoblastoma in Sotos syndrome, retinoblastoma in Arima syndrome and ovarian cancer in Noonan syndrome using SNP-genotype microarrays. Several unknown copy number changes including high-grade amplification of 2q24, gain of chromosome 2 and uniparental disomy of 18p were identified in these tumors. Our results suggest that candidate target genes involved in the pathogenesis of complicated tumors would be exist within the regions showing copy number abnormalities.
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[Presentation] 小児卵黄嚢腫瘍の微小再発巣や遠隔転移巣検出におけるFDG-PETの有用性2010
Author(s)
高橋正貴, 金森豊, 鈴木完, 小高哲郎, 寺脇幹, 古村眞, 杉山正彦, 本村あい, 滝田順子, 井田孔明, 岩中督
Organizer
第26回日本小児がん学会学術集会
Place of Presentation
大阪
Year and Date
20101217-20101219
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[Presentation] Refractory Ewing Sarcoma family of tumors in a child with EWS-FEV fusion gene.2010
Author(s)
Motomura A, Takita J, Nishimura R, Ohki K, Ohkubo J, Ida K, Kikuchi A, Okita H, Ogawa S, Igarashi T
Organizer
The 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association
Place of Presentation
Taipei, Taiwan
Year and Date
20100415-20100418
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[Presentation] 急性リンパ性白血病の加療中に肺動脈塞栓症、肺アスペルギローマを合併し1期的に切除しえた1例2010
Author(s)
村山智紀, 小林宏彰, 土屋武弘, 日野春秋, 長山和弘, 村川知弘, 中島淳, 森岡まさき, 中釜悠, 本村あい, 滝田順子
Organizer
第154回日本胸部外科学会関東甲信越地方会
Place of Presentation
東京
Year and Date
2010-11-13
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[Presentation] 小児固形腫瘍におけるALK阻害剤の感受性2009
Author(s)
本村あい, 滝田順子, 大木健太郎, 西村力, 加藤元博, 陳玉彦, 真田昌, 菊地陽, 五十嵐隆, 林康秀, 小川誠司
Organizer
第68回日本癌学会学術総会
Place of Presentation
横浜
Year and Date
20091001-20091003
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