2011 Fiscal Year Final Research Report
Structural studies on IL-18 ligand receptor complex for designing new drugs of allergy and autoimmune diseases
| Project/Area Number |
21790979
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
KIMURA Takeshi 岐阜大学, 医学部・附属病院, 助教 (60422705)
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| Project Period (FY) |
2009 – 2011
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| Keywords | IL-18 / 構造解析 |
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| Research Abstract |
Inter leukin-18(IL-18), found as interferon-γinducing factor, plays a critical role in innate and acquired immune response against microbes. IL-18 would also contribute to the pathogenesis of inflammatory diseases. To elucidate the pathogenesis and structure of IL-18 I igand-receptor complex, we have expressed recombinant IL-18Rαand IL-18Rβwith baculo-Insect cell systems and crystallized it as IL-18/IL18Rα/IL-18Rβheterotr imer ic complex and obtained X-ray diffraction data from the crystal.
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Research Products
(2 results)
