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2010 Fiscal Year Final Research Report

Tissue-specific roles of inositol 1,4,5-trisphosphate receptors for cardiovascular development

Research Project

  • PDF
Project/Area Number 21791004
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKeio University

Principal Investigator

UCHIDA Keiko  Keio University, 医学部, 共同研究員 (50286522)

Project Period (FY) 2009 – 2010
Keywords発生 / 循環器 / シグナル伝達
Research Abstract

We previously showed that inositol 1, 4, 5-trisphosphate receptor (IP3R) 1 and 3 double knockout (1/3DKO) mice exhibited the defect of cardiovascular development. Our results from the marker analyses and the generation of tissue-specific 1/3DKO mice suggested that IP3R1 and 3 do not function in the subpopulation of the second heart field originated from Tbx1 expressed cells during heart development, and that IP3R1 and 3 in the endothelial cells may play redundant roles for the angiogenesis during embryonic vascular development.

  • Research Products

    (5 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field.2011

    • Author(s)
      Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H.
    • Journal Title

      Journal of Molecular and Cellular Cardiology (in press).

    • Peer Reviewed
  • [Journal Article] Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.2010

    • Author(s)
      Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H.
    • Journal Title

      PloS ONE 5

      Pages: e12500

    • Peer Reviewed
  • [Journal Article] Molecular embryology for an understanding of congenital heart diseases.2009

    • Author(s)
      Yamagishi H, Maeda J, Uchida K, Tsuchihashi T, Nakazawa M, Aramaki M, Kodo K, Yamagishi C.
    • Journal Title

      Anatomical Science International 84

      Pages: 88-94

    • Peer Reviewed
  • [Presentation] Type 1 and 3 Inositol 1,4,5-Trisphosphate Receptors in the Endotheliumare Required for Angiogenesis during Embryonic Vascular Development2010

    • Author(s)
      内田敬子
    • Organizer
      アメリカ心臓学会
    • Place of Presentation
      マコーミックプレイス(米国、シカゴ)
    • Year and Date
      2010-11-16
  • [Remarks] ホームページ等 なし

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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