Mechanism of L-asparaginase-induced pancreatitis and its prophylaxis using octreotide

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791010
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Juntendo University
• Principal Investigator: SUZUKI Mitsuyoshi Juntendo University, 医学部, 助教 (90449059)
• Project Period (FY): 2009 – 2010
• Keywords: 薬剤性膵炎 / 急性白血病 / L-asparaginase

Research Abstract

We demonstrated that in patients receiving ASNase therapy, the serum trypsin and pancreatic secretory trypsin inhibitor levels are usually elevated due to subclinical pancreatitis induced by the treatment. Futher, the mechanism of ASNase-induced pancreatic injury may involve an imbalance of the protease-antiprotease, such as, α1-antitrypsin, α2-macroglobulin. The present result also suggested that ASNase treatment with octreotide appears useful in prevent this complication in recovering patients.

Research Products

• [Journal Article] Acute pancreatitis in a 2-year-old girl on peritoneal dialysis and using icodextrin solution. (2011)
  • Author(s): Fujinaga S, Nishizaki N, Hirano D, Kanai H, Suzuki M, Ohtomo Y, Kaneko K, Shimizu T
  • Journal Title: Clin Nephrol 75 Pages: 89-90
• [Journal Article] IGF-I, leptin and active ghrelin levels in very low birth weight infants during the first 8 weeks of life. (2010)
  • Author(s): Ohkawa N, Shoji H, Kitamura T, Suganuma H, Yoshikawa N, Suzuki M, Lee T, Hisata K, Shimizu T
  • Journal Title: Acta Paediatr 99 Pages: 37-41
• [Journal Article] Phenotypic overlapping of trisomy 12p and Pallister-Killian syndrome. (2010)
  • Author(s): Inage E, Suzuki M, Minowa K, Akimoto N, Hisata Ken, Shoji H, Okumura A, Shimojima K, Shimizu T, Yamamoto T
  • Journal Title: Eur J Med Genet 53 Pages: 159-161
• [Journal Article] Spontaneous shrinkage of a solid pseudopapillary tumor of the pancreas : CT (2010)
  • Author(s): Suzuki M, Shimizu T, Minowa K, Ikuse T, Baba Y, Ohtsuka Y.
  • Journal Title: findings : Pediatr Int 52 Pages: 335-336
• [Journal Article] Laboratory evaluation of blood plasma separation device in children. (2010)
  • Author(s): Suzuki M, Minowa K, Tokita A, Fujimura J, Haruna H, Someya T, Shimizu T
  • Journal Title: Pediatr Int 52 Pages: 891-892
• [Journal Article] 【必携小児の薬の使い方】疾患に対する薬剤の選び方・使い方と注意消化器疾患 急性膵炎 (2010)
  • Author(s): 鈴木光幸
  • Journal Title: 小児内科 42 Pages: 484-487
• [Journal Article] 【ここまでわかっている自己抗体と自己免疫疾患】自己免疫性膵炎 (2010)
  • Author(s): 鈴木光幸, 清水俊明
  • Journal Title: 小児科診療 73 Pages: 2175-2180
• [Journal Article] Peginterferon alpha-2b and ribavirin for the treatment of chronic hepatitis C in Japanese pediatric and young adult patients : a survey of the Japan Society of Pediatric Hepatology. (2009)
  • Author(s): Tajiri H, Inui A, Kiyohara Y, Suzuki M, Kagimoto S, Etani Y, Shimizu T, Fujisawa T
  • Journal Title: Eur J Gastroenterol Hepatol 21 Pages: 1256-1260
• [Journal Article] Estimation of postoperative fat absorption using the ^<13>C mixedtriglyceride breath test in children with choledochal cyst. (2009)
  • Author(s): Suzuki M, Tanaka K, Ohtani K, Kitamura K, Kudo T, Shoji H, Suzuki R, Shimizu T
  • Journal Title: Eur J Pediatr 168 Pages: 35-38
• [Journal Article] 尿中硫酸飽合型胆汁酸分析の実際-1,153例の解析結果から- (2009)
  • Author(s): 鈴木光幸
  • Journal Title: 広島県小児科医会会報 47 Pages: 25-26
• [Journal Article] 小児期の急性膵炎 (2009)
  • Author(s): 清水俊明, 鈴木光幸
  • Journal Title: 小児科 50 Pages: 1511-1520
• [Presentation] 小児の特発性膵炎症例に対するPRSS1およびSPINK1遺伝子解析 (2010)
  • Author(s): 鈴木光幸, 箕輪圭, 青柳陽, 藤井徹, 工藤孝広, 清水俊明
  • Organizer: 第37回日本小児栄養消化器肝臓病学会
  • Year and Date: 20101008-20101010
• [Presentation] Fontan術後遠隔期合併症によるうっ血性肝硬変の一剖検例 (2010)
  • Author(s): 鈴木光幸, 箕輪圭, 鳥羽山寿子, 古川岳史, 佐藤圭子, 秋元かつみ, 清水俊明
  • Organizer: 第43回武蔵野小児肝臓病懇話会
  • Year and Date: 2010-12-06
• [Presentation] 家族歴のある非症候性胆管減少症の1男児例 (2010)
  • Author(s): 鈴木光幸, 箕輪圭, 清水俊明, 工藤豊一郎, 須磨崎亮
  • Organizer: 第42回武蔵野小児肝臓病懇話会
  • Year and Date: 2010-07-06
• [Presentation] 小児領域における薬剤性膵炎の臨床的検討 (2009)
  • Author(s): 鈴木光幸, 箕輪圭, 青柳陽, 藤井徹, 藤武義人, 大塚宜一, 清水俊明
  • Organizer: 第36回小児栄養消化器肝臓病学会
  • Year and Date: 20091009-20091011
• [Presentation] Scoring System for the Severity of Acute Pancreatitis in Children (2009)
  • Author(s): Suzuki M, Minowa K, Baba Y, Aoyagi Y, Fujii T, Fujitake T, Kudo T, Ohtsuka Y, Shimizu T
  • Organizer: 11th Congress of the Asian Pan-Pacific Society of Pediatric Gastroenterology, Hepatology and Nutrition
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20090925-20090928
• [Presentation] 小児・若年成人におけるC型慢性肝炎に対するPEG-IFN/Ribavirin併用療法の治療成績 (2009)
  • Author(s): 鈴木光幸, 箕輪圭, 時田章史, 大塚宜一, 清水俊明
  • Organizer: 第112回日本小児科学会学術集会
  • Year and Date: 20090417-20090419
• [Book] 小児臨床栄養学 疾患別の栄養法 消化器疾患 急性膵炎・急性慢性(児玉浩子,清水俊明(編)) 東京 (2011)
  • Author(s): 鈴木光幸
  • Total Pages: 230-234
  • Publisher: (株)診断と治療社
• [Book] 小児科臨床ピクシス【○!9】川崎病のすべて急性期の肝機能(石井正浩(編)) 東京 (2009)
  • Author(s): 鈴木光幸, 清水俊明
  • Total Pages: 82-83
  • Publisher: (株)中山書店
• [Book] 小児科臨床ピクシス【○!8】小児プライマリケアクリニック内での感染予防(横田俊一郎(編)) 東京 (2009)
  • Author(s): 時田章史,鈴木光幸
  • Total Pages: 7-9
  • Publisher: (株)中山書店
• [Remarks] ホームページ等 なし