2011 Fiscal Year Final Research Report
Analysis of genes involved inβ-catenin degradation in nephroblastoma
| Project/Area Number |
21791021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | 埼玉県立がんセンター (2011)
Research Institute for Clinical Oncology, Saitama Cancer Center (2009-2010) |
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Principal Investigator |
HARUTA Masayuki 埼玉県立がんセンター, 臨床腫瘍研究所, 研究員 (80392190)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腎芽腫 / 遺伝子異常 |
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| Research Abstract |
More than half of nephroblastoma didn't show abnormalities in responsible genes for tumorigenesis in fetal kidney. Therefore, there may be mutations in other tumor suppressor genes. Abnormalities of WTX and CTNNB known as tumor suppressor genes involved in WNT signaling pathway were detected in 22.8% and 26.3% of the 114 nephroblastomas. SNP array analysis clarified chromosomal abnormalities of APC(5q21-22), AXIN1(16p13) or AXIN2(17q23-24) coding regions in a little bit of cases. By direct sequencing analysis, a mutation of APC gene was indentified in one of 59 tumors which didn't have any abnormalities in known responsible genes. Patients with an abnormality in WTX gene were poor outcome than those without(p=0.0402).
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[Journal Article] Different incidences ofepigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children2012
Author(s)
M, AraiY, Watanabe N, Fujiwara Y, Honda S, Ohshima J, Kasai F, Nakadate H, Horie H, Okita H, Hata JI, Fukuzawa M, Kaneko Y
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Journal Title
Cancer Sci
Volume: (in press)
Peer Reviewed
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[Journal Article] Methylation of the RASSF1A promoteris predictive of poor outcome among patients with Wilms tumor2012
Author(s)
Ohshima J, Haruta M, Fujiwara Y, WatanabeN, Arai Y, Ariga T, Okita H, Koshinaga T, Oue T, Hinotsu S, Nakadate H, Horie H, Fukuzawa M, Kaneko Y
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Journal Title
Pediatr Blood Cancer
Volume: (in press)
Peer Reviewed
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[Journal Article] Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma2010
Author(s)
Arai Y, Honda S, Haruta M, Kasai F, Fujiwara Y, Ohshima J, Sasaki F, Nakagawara A, Horie H, Yamaoka H, Hiyama E, Kaneko Y.
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Journal Title
Genes Chromosomes Cancer
Volume: 49
Pages: 596-609
Peer Reviewed
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[Journal Article] Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilm stumor2009
Author(s)
Ohshima J, Haruta M, Arai Y, Kasai F, Fujiwara Y, Ariga T, Okita H, Fukuzawa M, Hata J, Horie H, Kaneko Y
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Journal Title
Genes Chromosomes Cancer
Volume: 48
Pages: 1037-50
Peer Reviewed
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