Elucidated of environmental and genetic effects on the neural network disorders.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791036
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: MATSUMOTO Yoshiki Kagawa University, 農学部, 助教 (90335844)
• Project Period (FY): 2009 – 2010
• Keywords: ニューラルネットワーク / アルコール曝露動物 / 幹細胞性の保持 / 神経変性疾患 / 環境要因 / 迷走神経

Research Abstract

In this study, we elucidated the effects of environmental and genetic cues for the neural network formations. First, to clarify the response of environmental stress were analyzed using neuronal progenitor cells. Those effects and related signal transcription on neuro-progenitor cells were clearly promoted rescue on cell cycle and neuronal stretched shapes. It may have been involving survival response in neuro progenitor cell that was expressing the receptor of neuronal growth factors and that shown responsible for several environment cues. Interestingly, neuronal injured adult rat brain indicated similar morphological alteration that has promoted the autocrine-like and diacrine-like formation at pre- and post- synaptic membrane during a non-excitable condition.

Research Products

• [Journal Article] Yoshiki Takeuchi Revaluation of neuronal contacts with pituicytes in the rat posterior pituitary (2011)
  • Author(s): Jun-Qian Liu, Takanori Miki, Katsuhiko Warita, Ken-ichi Ohta, Tomiko Yakura, Yoshiki Matsumoto
  • Journal Title: Current Neurobiology 2 Pages: 1-4
  • Peer Reviewed
• [Journal Article] Nuclear Orphan Receptor TLX Induces Oct-3/4 for the Survival and Maintenance of Adult Hippocampal Progenitors upon Hypoxia. (2011)
  • Author(s): Chavali PL, Saini RK, Matsumoto Y, Agren H, Funa K.
  • Journal Title: The Journal of Biological Chemistry 286(11) Pages: 404-9393
  • Peer Reviewed
• [Journal Article] Modulation of the hypothalamopituitary axis in Mini rat: Further studies with hypophysiotropic somatostatin and gonadotroph cells. (2010)
  • Author(s): Matsumoto Y
  • Journal Title: Current Neurobiology 1 Pages: 103-10
  • Peer Reviewed
• [Journal Article] Sharing first authorship.TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors. (2010)
  • Author(s): Elmi M, Matsumoto Y, Zeng ZJ, Chavali PL, Yang W, Uemura A, Nishikawa S, Moshiri A, Tajima N, Agren H, Funa K.
  • Journal Title: Molecular and Cellular Neuroscience 45 Pages: 121-131
  • Peer Reviewed
• [Journal Article] Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum. (2010)
  • Author(s): Wang ZY, Miki T, Lee KY, Yokoyama T, Kusaka T, Sumitani K, Warita K, Matsumoto Y, Yakura T, Hosomi N, Ameno K, Bedi KS, Takeuchi Y.
  • Journal Title: Neuroscience 165 Pages: 485-491
  • Peer Reviewed
• [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus. (2010)
  • Author(s): Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, S Bedi K, Itoh S, Nakamura Y, Takeuchi Y.
  • Journal Title: Acta Neurobiol Exp(Wars) 68 Pages: 49-484
  • Peer Reviewed
• [Journal Article] Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors: No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus. (2010)
  • Author(s): UenoT, Miki T, Wang ZY, Yokoyama T, Lee KY, Kusaka T, Warita K, Sumitani K, Matsumoto Y, Yakura T, Liu JQ, Bedi KS, Takeuchi Y.
  • Journal Title: Current Neurobiology 1 Pages: 40-45
  • Peer Reviewed
• [Journal Article] GABA expression in c-Fos immunoreactive neurons of the rat periaqueductal gray induced by electroacupuncture at the point of Zusanli. (2010)
  • Author(s): Fusumada K, Yokoyama T, Miki T, Matsumoto Y, Warita K, Wang ZY, Yakura T, Liu JQ, Takeuchi Y.
  • Journal Title: Current Neurobiology 1 Pages: 10-13
  • Peer Reviewed
• [Journal Article] Nerve growth factor and receptors are significantly affected by histamine stimulus through H1 receptor in pancreatic carcinoma cells. (2010)
  • Author(s): Wang ZY, Ding Y, Miki T, Warita K, Matsumoto Y, Takeuchi Y, Wang SJ, Feng JG, Liu W, Wang YD, Wang XL, Wang YH, Liu Y, Shan BE.
  • Journal Title: Molecular Medicine Reports 3 Pages: 103-109
  • Peer Reviewed
• [Journal Article] Anterograde synaptic transport of neuronal tracer enzyme (WGA-HRP): Further studies with Rab3A-siRNA in rats.
  • Author(s): Takeuchi Y, Matsumoto Y, Miki T, Yokoyama T, Warita K, Wang ZY, Ueno T, Yakura T, Fujita M.
  • Journal Title: Biomedical Research 20 Pages: 15-149
  • Peer Reviewed
• [Presentation] Synaptic transcytosis of HRP-labbeled marker proteins. (2011)
  • Author(s): Takeuchi Y, Miki T, Warita K, Ohta K, Yakura T, Liu JQ, Matsumoto Y.
  • Organizer: The Japanese Society of Microscopy
  • Place of Presentation: 福岡市・福岡国際会議場(Invited speaker)
  • Year and Date: 20110516-20110518
• [Presentation] Morphmetric aspects of villous membrane structure in animal science. (2011)
  • Author(s): Matsumoto Y, Takeuchi Y, Yamauchi KE.
  • Organizer: The Japanese Society of Microscopy
  • Place of Presentation: 福岡市・福岡国際会議場(Invited speaker)
  • Year and Date: 20110516-20110518
• [Presentation] Neuronal transcytosis of WGA-amyloid beta complex in the rat. (2011)
  • Author(s): Matsumoto Y, Liu JQ, Miki T, Warita K, Ohta K, Yakura T, Takeuchi Y.
  • Organizer: The 166th Annual meeting of the Japanese Association of Anatomists
  • Place of Presentation: (震災特例として誌上発表)
  • Year and Date: 20110300
• [Presentation] Neuronal transcytosis of protein:application for Amyloid-β in vivo (2010)
  • Author(s): Matsumoto Y, Miki T, Warita K, Takeuchi Y
  • Organizer: 日本神経科学会
  • Place of Presentation: 神戸市・国際会議場
  • Year and Date: 20100902-20100904
• [Presentation] An approach for decrease of β-amyloid deposits in neuron. (2010)
  • Author(s): Matsumoto Y, Miki T, Warita K, Yakura T, T.Liu JQ, Takeuchi Y.
  • Organizer: 第50回日本先天異常学会学術集会
  • Place of Presentation: 淡路市・淡路夢舞台国際会議場
  • Year and Date: 20100708-20100710
• [Presentation] A protein conjugation of WGA essential for transsynaptic tracer in neuronal system: application for Amyloid-β in vivo. (2009)
  • Author(s): Takeuchi Y, Matsumoto Y, Miki T, Warita K, Liu JQ.
  • Organizer: The International Symposium on Eary Detectoin and Rehabilitaion Technology of Dementia
  • Place of Presentation: 岡山市・岡山大学
  • Year and Date: 20091211-20091212
• [Presentation] Modulation of the hypothalamopituitary axis in Mini rat: Further studies with hypophysiotropic somatostatin and gonadotroph cells. (2009)
  • Author(s): Matsumoto Y, Miki T, Tukamoto Y, Warita K, Wang ZY, Yakura T, Agren N, Karasawa S, Ueda S,Takeuchi Y.
  • Organizer: 8th World Congress on Neurohypophysial Hormones
  • Place of Presentation: 北九州市・国際会議場
  • Year and Date: 20090904-20090908
• [Presentation] 体温調節能確立直後における寒冷刺激がもたらす消化吸収機能への影響
  • Author(s): 松本由樹、山内高圓
  • Organizer: 日本家禽学会2011年度春季学会
  • Place of Presentation: (震災特例として誌上発表)
• [Book] Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications, Chapter 21th, Neuronal transcytosis of WGA conjugated protein: a new approach to Amyloid-β in vivo, (2011)
  • Author(s): Takeuchi Y, Matsumoto Y, Miki T, Warita K, Liu JQ.
  • Total Pages: 162-166
  • Publisher: IGI-global press