The exhaustive analysis of signal transducing molecules contributing to neonatal brain development in breast milk

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791045
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kanazawa Medical University
• Principal Investigator: SIMAMURA Eriko Kanazawa Medical University, 医学部, 講師 (00267741)
• Research Collaborator: HATTA Toshihisa 金沢医科大学, 医学部, 教授 (20238025) ; TOMOSUGI Naohisa 金沢医科大学, 医学部, 教授 (80155580) ; ISHIGAKI Yasuhito 金沢医科大学, 付置研究所, 講師 (20232275)
• Project Period (FY): 2009 – 2010
• Keywords: 新生児医療 / 未熟児 / 中枢神経 / 発生学 / 母乳

Research Abstract

We identified candidate proteins which are relevant with brain development by proteomics and DNA micro array analysises of rat colostrum. The new artificial rearing system for rat neonates was established to be able to administer small amounts of neurogenetic factors exactly to neonates per os under complete nutritional care, providing new in vivo model to evaluate candidates affecting the postnatal brain development.

Research Products

• [Journal Article] Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway. (2010)
  • Author(s): Simamura E, Shimada H, Higashi N, Uchishiba M, Otani H, Hatta T.
  • Journal Title: Endocrinology 151 Pages: 1853-1862
  • Peer Reviewed
• [Journal Article] Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase. (2009)
  • Author(s): Shimada H, Hirai K-I, Simamura E, Hatta T, Iwakiri H, Mizuki K, Hatta T, Sawasaki T, Matsunaga S, Endo Y, Shimizu S.
  • Journal Title: J Biol Chem 284 Pages: 28642-28649
  • Peer Reviewed
• [Journal Article] The effects of melanocortins on fetal development.
  • Author(s): Simamura E, Shimada H, Shoji H, Otani H, Hatta T.
  • Journal Title: Congenit Anonm (Review)(in press)
  • Peer Reviewed
• [Presentation] ラット胎児連続切片のバーチャルスライドライブラリーの構築 (2011)
  • Author(s): 内芝舞実, 島村英理子, 島田ひろき, 東伸明, 増田浩子, 八田稔久
  • Organizer: 第116日本解剖学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2011-03-28
• [Presentation] Alteratio of gene expression profiles in the fetal cerebrum after injection of leukemia inhibitory factor into dams (2010)
  • Author(s): T.Hatta, H.Shimada, E.Simamura, Y.Ishigaki, N.Higashi, T.Tatsuno, F.Takano
  • Organizer: Society for NEUROSCIENCE 2010
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-15
• [Presentation] 大動脈腹側枝と背側枝の派出位置について (2010)
  • Author(s): 東伸明, 島田ひろき, 島村英理子, 八田稔久
  • Organizer: 第70回日本解剖学会中部支部学術集会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-10-16
• [Presentation] The regulation of fetal neurogenesis via maternal-fetal LIF-ACTH-LIF signaling relay pathway (2010)
  • Author(s): 島村英理子, 島田ひろき, 東伸明, 内芝舞実, 大谷浩, 八田稔久
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 兵庫
  • Year and Date: 2010-09-02
• [Presentation] 赤血球脱核誘導因子による成熟赤血球の培養法 (2010)
  • Author(s): 島村英理子, 増田浩子, 島田ひろき, 東海林博樹, 村上学, 東伸明, 八田稔久
  • Organizer: 第46回金沢医科大学医学会学術集会
  • Place of Presentation: 内灘
  • Year and Date: 2010-07-17
• [Presentation] 胎盤を介した母胎問シグナルリレーLIF-ACTH-LIFによる胎児発生調節機構 (2010)
  • Author(s): 島村英理子
  • Organizer: 第50回日本先天異常学会学術集会(奨励賞授賞講演)
  • Place of Presentation: 淡路島
  • Year and Date: 2010-07-08
• [Presentation] 胎盤を介した母胎問シグナルリレーLIF-ACTH-LIFの時期特異性 (2010)
  • Author(s): 島村英理子, 島田ひろき, 東伸明, 内芝舞実, 大谷浩, 八田稔久
  • Organizer: 日本先天異常学会第50回学術集会
  • Place of Presentation: 淡路島
  • Year and Date: 2010-07-08
• [Presentation] ビスフェノールAのマウス下顎頭に及ぼす影響 (2010)
  • Author(s): 金山景錫, 八田稔久, 島村英理子, 島田ひろき, 瀬上夏樹
  • Organizer: 第50回日本先天異常学会学術集会
  • Place of Presentation: 淡路
  • Year and Date: 2010-07-08
• [Presentation] ラット初乳中の蛋白,ペプチド成分のプロファイリング (2010)
  • Author(s): 島田ひろき, 島村英理子, 内芝舞実, 東伸明, 増田浩子, 高田尊信, 土田秀行, 石垣靖人, 友杉直久, 八田稔久
  • Organizer: 第50回日本先天異常学会学術集会
  • Place of Presentation: 淡路島
  • Year and Date: 2010-07-08
• [Presentation] 腹大動脈腹側枝の派出位置の計測 (2010)
  • Author(s): 東伸明, 島田ひろき, 島村英理子, 八田稔久
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-03-30
• [Presentation] Maternal leukemia inhibitory factor enhances proliferation of neuronal progenitors of forebrain in rat fetuses (2009)
  • Author(s): T.Hatta, E.Simamura, H.Shimada, M.Uchishiba, N.Higashi
  • Organizer: Society for NEUROSCIENCE 2009
  • Place of Presentation: Chicago
  • Year and Date: 20091017-20091021
• [Presentation] Leukemia inhibitory factor level in cerebrospinal fluid is elevated via placental adrenocorticotropic hormone in rat fetuses (2009)
  • Author(s): E.Simamura, H.Shimada, N.Higashi, H.Otani, T.Hatta
  • Organizer: Society for NEUROSCIENCE 2009
  • Place of Presentation: Chicago
  • Year and Date: 20091017-20091021
• [Presentation] 標準型腹腔動脈について (2009)
  • Author(s): 東伸明, 島田ひろき, 島村英理子, 八田稔久
  • Organizer: 第68回中部支部学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20091000
• [Presentation] Analysis of materna1-fetal LIF-ACTH-LIF signaling pathrogy (2009)
  • Author(s): E.Simamura, H.Shimada, N.Higashi, H.Otani, T.Hatta
  • Organizer: 第49回日本先天異常学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 20090625-20090627
• [Presentation] Maternal LIF contributes to fetal development via a LIF-ACTH-LIF signaling relay pathway (2009)
  • Author(s): T.Hatta, E.Simamura, H.Otani
  • Organizer: International Symposium Analyses of Developmental Phenomena : Toward the elucidation of the developmental origins of diseases
  • Place of Presentation: Izumo
  • Year and Date: 2009-10-30
• [Presentation] 母胎問LIFネットワークによる胎児脳の発育調節 (2009)
  • Author(s): 八田稔久, 島村英理子, 島田ひろき, 東伸明
  • Organizer: 第45回金沢医大医学会
  • Place of Presentation: 内灘
  • Year and Date: 2009-07-25
• [Remarks] ホームページ
  • URL: http://www.kanazawa-med.ac.ip/~anatomy1/index.html
• [Patent(Industrial Property Rights)] 有核赤血球の脱核方法及び脱核誘導剤 (2010)
  • Inventor(s): 八田稔久、島村英理子、島田ひろき
  • Industrial Property Rights Holder: 学校法人金沢医科大学
  • Industrial Property Number: PGT/JP2010,001217
  • Filing Date: 2010-02-23
  • Overseas