Doesaggressiveintravenousnutritionimprovedevelopmentofpreterminfants?-Eliminatingextrauterinegrowthrestriction.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21791047
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kurume University
• Principal Investigator: IWATA Sachiko 久留米大学, 医学部, 助教 (40465711)
• Co-Investigator(Kenkyū-buntansha): IWATA Osuke 久留米大学, 医学部, 助教 (30465710)
• Project Period (FY): 2009 – 2011
• Keywords: 方向性拡散強調画像 / 栄養 / 早期産児 / FractionalAnisotropy / 発達障害 / 白質障害 / 磁気共鳴診断 / 予後

Research Abstract

In a study which investigated the relationship between conventional brain MRI at term and the cognitive outcome at 9 years old in very preterm-born infants, significant correlations were observed between the white matter injury and cognitive, language and motor impairment. In another study using diffusion tensor imaging at term in 82 preterm infants, fractional anisotropy of the white matter was linearly correlated with the postconception age of the infant. Participants were also assessed for the neurodevelopmental outcome at 18 and 36 months of post-natal corrected age ; detailed relationships between background clinical variables during the neonatal period including nutrition and quantitative MRI markers and neurodevelopmental outcomes are currently under analysis.

Research Products

• [Journal Article] Qualitative brain MRI at term and cognitive outcomes at 9 years old following verypreterm birth (2012)
  • Author(s): Iwata S, Iwata 0, et al.
  • Journal Title: Pediatrics Volume: 129(5) Pages: 1138-1147
  • Peer Reviewed
• [Journal Article] Hypothermia for neonatal encephalopathy : Nationwide Survey of Clinical Practice in Japan as of August 2010 (2012)
  • Author(s): Iwata 0, Iwata S, et al.
  • Journal Title: Acta Paediatr Volume: 101(5) Pages: e197-e202
  • Peer Reviewed
• [Journal Article] Past, present and future of hypothermic neuroprotection for neonatal encephalopathy in Japan : Time to say good-by to the old remedies (2012)
  • Author(s): Iwata 0, Takenouchi T.
  • Journal Title: Brain Dev Volume: 34(2) Pages: 163-4
  • Peer Reviewed
• [Journal Article] Filling the evidence gap : how can we improve the outcome of neonatal encephalopathy in the next 10 years(Review) (2011)
  • Author(s): Iwata O, Iwata S
  • Journal Title: Brain Dev Volume: 33(3) Pages: 221-8
  • Peer Reviewed
• [Journal Article] Subtle white matter injury is common in term-born infants with a wide range of risks (2010)
  • Author(s): Iwata S, Iwata O. et al.
  • Journal Title: Int J Dev Neurosci Volume: 28(7) Pages: 573-80
  • Peer Reviewed
• [Presentation] 方向性拡散強調画像を用いた新生児脳の発達評価FA、ADCを用いた定量的検討 (2011)
  • Author(s): 大矢崇志, 岩旦圭王, 才津宏樹, 海野光昭, 岡田純一郎, 神田洋, 前野泰樹, 岩旦欧允, 松石豊次郎
  • Organizer: 日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-12
• [Presentation] ハイリスク児の成長と脳の微細構造 (2011)
  • Author(s): 木下正啓, 田中祥一朗, 海野光昭, 才津宏樹, 岡田純一郎, 岩旦圭王, 神田洋, 松石豊治郎, 前野泰樹, 岩田欧介
  • Organizer: 日本周産期・新生児医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-10
• [Presentation] ベッドサイドにおける新生児の脳成熟度評価の試み (2011)
  • Author(s): 大矢崇志, 岩且圭王, 永光信一郎, 山下裕史朗, 岩旦致企, 松石豊次郎
  • Organizer: 日本小児神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-05-26
• [Presentation] 新生児の脳温決定因子の検討 (2010)
  • Author(s): 岩且幸子, 岩旦欧介, 大矢崇志, 松石豊次郎
  • Organizer: 日本小児神経学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-05-22
• [Book] Consensus2010に基づく新生児低体温療法実践マニュアル (2011)
  • Author(s): 田村正徳, 岩田欧介, 岩且圭壬, 鍋谷まこと, 武内俊樹
  • Publisher: 東京医学社
• [Book] 新生児・小児のための脳低温療法一日本脳低温療法学会公認テキスト (2011)
  • Author(s): 茨聡, 岩田欧介, 徳久琢也, 他
  • Publisher: メディカ出版