2011 Fiscal Year Final Research Report
Elucidation of mechanisms developing BFNC with poor outcome using KCNQ2 knock-in mouse model
| Project/Area Number |
21791048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
NAKAMURA Yuki 福岡大学, てんかん分子病態研究所, 研究員 (90535072)
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| Project Period (FY) |
2009 – 2011
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| Keywords | てんかん / イオンチャネル / 遺伝子 / 電気生理 / 変異体 / カリウムチャネル / 過分活性化環状ヌクレオチド依存性チャネル / 熱性けいれん |
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| Research Abstract |
A novel missense mutation(S126L) in HCN2 was identified from febrile seizure(FS) patients. As bath temperature was raised at 38.C, V_1/2 of mutant channels shifted depolarized side and fast time constant of mutant channels accelerated compared with wild-type channels. There was no significant difference between wild-type and mutant channels about responses to cyclic AMP(cAMP). These results suggest that this mutation might alter neuronal excitability during hyperthermia.
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