2010 Fiscal Year Final Research Report
Does maternal immune activation negatively affect fetal brain neuronal development?
| Project/Area Number |
21791050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
OH-NISHI Arata National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 (00507014)
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| Project Period (FY) |
2009 – 2010
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| Keywords | インフルエンザ感染 / 妊娠 / 胎児脳神経発達 / 海馬 / シナプス / サイトカイン / ケモカイン / 免疫 |
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| Research Abstract |
Influence of maternal immune activation on neurodevelopment of fetal brain is not well understood. We investigated that influence of maternal immune activation by stranded RNA polyriboinosinic-polyribocytidilic acid administration on hippocampal pathology and synaptic function in juvenile offspring. In hippocampal CA1 region from juvenile offspring of Poly I:C treated dams, presynaptic fiver volley amplitude and field excitatory post synaptic potential slope were significant lower than control rats. In addition, short synaptic plasticity namely paired pulse facilitation ratio was significant higher and long-term potentiation impaired in hippocampal CA1 region from juvenile offspring of poly IC treated dams. In contrast, there were no effects in the hippocampal histology and neuronal nuclears antigen positive cell number from postnatal offspring of poly IC treated dams. Maternal immune activation causes of hippocampal synaptic dysfunction but not neuronal loss in the postnatal periods.
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