2010 Fiscal Year Final Research Report
Development of therapeutic strategies for periventricular leukomalacia based on the activation of microglia and the inhibition of inflammatory mediatior.
| Project/Area Number |
21791051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
TAKEI Shiro Institute for Developmental Research, Aichi Human Service Center, 病理学部, リサーチレジデント (60398576)
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| Research Collaborator |
SHIMADA Atsuyoshi 愛知県心身障害者コロニー発達障害研究所, 病理学部, 室長 (50311444)
CHIBA Yoichi 愛知県心身障害者コロニー発達障害研究所, 病理学部, 主任研究員 (30372113)
SHIMIZU Takao 東京大学, 医学部, 教授 (80127092)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳室周囲白質軟化症 / プロスタグランジン / ミクログリア / 脂質メディエーター |
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| Research Abstract |
Although periventricular leukomalacia (PVL) is one of the most common brain injuries in premature infants, there has been no effective treatment. We investigated the mechanism of PVL in relationship to microglia. We found that hematopoietic prostaglandin D synthase and microsomal prostaglandin E synthase were upregulated in glial cytoplasms in white matter of infant brains during hypoxic/ischemic (H/I) insults following maternal infection. We suggest that these prostaglandins may elevated the risk of PVL via microglial activation.
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