2010 Fiscal Year Final Research Report
Molecular Basis of Intolerance Against Hair Graying : Active Roles of PI3K and Stat3 Pathways
Project/Area Number |
21791058
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Dermatology
|
Research Institution | Akita University |
Principal Investigator |
KAWAMURA Nanami Akita University, 医学部, 助教 (70323152)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 白髪化 / PTEN / PI3K / STAT3 |
Research Abstract |
In this grant program, we attempted to elucidate the biological roles of STAT3 and PI3Kγ during hair graying. The transgenic mouse studies showed that the genetic defect of both Stat3 and Pi3kγ genes enhance the radiosensitivity of malanocyte stem cells. These findings suggested that these molecules may play important roles in the maintenance of malanocyte stem cells.
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