Approaches of the new therapy development for atopic dermatitis by using RNA interference

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791064
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Osaka University (2010); Tokyo Medical and Dental University (2009)
• Principal Investigator: IGAWA Ken Osaka University, 医学系研究科, 講師 (00372441)
• Project Period (FY): 2009 – 2010
• Keywords: STAT6 / アレルギー / 治療

Research Abstract

Local administration of STAT6 siRNA (siRNA for STAT6) is a promising therapeutic strategy for both Th2-mediated cutaneous diseases and allergic rhinitis.

Research Products

• [Journal Article] Gene silencing of STAT6 with siRNA ameliorates contact hypersensitivity and allergic rhinitis. (2011)
  • Author(s): Hosoya K, Satoh T, Yamamoto Y, Saeki K, Igawa K(10人中5番目)
  • Journal Title: Allegy 66(1) Pages: 124-31
  • Peer Reviewed
• [Journal Article] 【アトピー性皮膚炎の正しい治療】アトピー性皮膚炎の新しい治療の展望 (2010)
  • Author(s): 井川健
  • Journal Title: 医薬ジャーナル 46(3) Pages: 994-998
  • Peer Reviewed
• [Presentation] 重症アトピー性皮膚炎の新規治療 (2010)
  • Author(s): 井川健
  • Organizer: 第109回日本皮膚科学会総会教育講演
  • Place of Presentation: 大阪
  • Year and Date: 20100416-20100418
• [Presentation] A therapeutic effect of ST AT6 inhibition in atopic dermatitis. (2009)
  • Author(s): Igawa K
  • Organizer: Yonsei Cutaneous Biology Research Institute International Symposium 2009
  • Place of Presentation: Seoul(招待講演)
  • Year and Date: 20090911-20090912