2011 Fiscal Year Final Research Report
Regulatory factor on binding of Desmoglein3 and p120ctn during blister formation in pemphigus
| Project/Area Number |
21791070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Gifu University |
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Principal Investigator |
SHU En 岐阜大学, 医学系研究科, 非常勤講師 (60444288)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 皮膚病理学 |
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| Research Abstract |
In order to elucidate the signal pathway of blister formation in pemphigus, we examined the phosphorylation of pl2Octn in keratinocytes treated with pemphigus-IgG.(1) We performed immunofluorescence staining with DJM-1 cells treated with pemphigus-IgG, however, phospho-p120ctn were not observed.(2) We stimulated normal human keratinocytes and subjected those cells to immunoprecipitation. There are no significant differences in phosphorylation of p120ctn between untreated cells, cells treated with pemphigus and normal human IgG.
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