2010 Fiscal Year Final Research Report
The effects of statin on lymphangiogenesis in impaired wound healing
| Project/Area Number |
21791086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
ASAI Jun Kyoto Prefectural University of Medicine, 医学研究科, 助教 (50438222)
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| Project Period (FY) |
2009 – 2010
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| Keywords | マクロファージ / リンパ管 / 創傷治癒 |
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| Research Abstract |
The present study showed topical application of simvastatin promoted lymphangiogenesis as well as angiogenesis during wound healing in genetically diabetic mice. These results suggested that both pre-existing lymphatic endothelial cells and infiltrating macrophages might contribute to newly organized vessels induced by simvastatin. In conclusion, a simple strategy of topically applied simvastatin may have significant therapeutic potential for enhanced wound healing in patients with impaired microcirculation such as occurs in diabetes.
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