2010 Fiscal Year Final Research Report
The analyses of mechanism to induce pemphigus using desmoglein 3-GFP transgenic mice
| Project/Area Number |
21791096
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
YOSHIDA Kazue Keio University, 医学部, 研究員 (70383776)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 天疱瘡 / デスモグレイン |
|---|
| Research Abstract |
Pemphigus vulgaris is serious autoimmune blistering disease induced by autoantibodies against desmoglein3 (Dsg3). To make Dsg3 visible, we made a Dsg3-GFP transgenic mouse. When we injected fluorescent labeling anti-Dsg3 antibody into Dsg3-GFP mouse ear skin, we have succeeded in observing the movement of Dsg3 and anti-Dsg3 antibody in vivo. Our observation would be useful to develop the disease-specific therapy to inhibit bulla formation in pemphigus vulgaris in the future.
|
