2010 Fiscal Year Final Research Report
Association between γδT cells abnormalities and pathogensis in sarcoidosis.
| Project/Area Number |
21791102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
UEDA Ikuko Kansai Medical University, 医学部, 助教 (80452100)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 皮膚生理学 / サルコイドーシス / γδT細胞 |
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| Research Abstract |
No significant differences in the absolute number of γδ T cells and the proportion of γδ T cells, and cell surface expression of CD62L and CD69 were observed in sarcoidosis patients. Abnormality of γδ T cells repertoire were observed ; the frequency of Vγ2+ cells was decreased and the frequency of Vγ9+ cells were increased in sarcoidosis patients compared to control. After the stimulation PMA plus ionomycin, γδ T cells from some patients have increased production of IFN-γ. It was confirmed that IFN-γ induced the proliferation of monocyte. γδ T cells may related to the pathogenesis of sarcoidosis by abnormal production of IFN-γ.
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Research Products
(2 results)
