2010 Fiscal Year Final Research Report
The role of Fra-2 and c-Myb in the oncogenesis of cutaneous T-cell lymphomas
| Project/Area Number |
21791103
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
NAKAYAMA Takashi Kinki University, 医学部, 講師 (60319663)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 癌 / 皮膚T細胞リンパ腫 / Fra-2 / AP-1 / c-Myb |
|---|
| Research Abstract |
In this study, we showed that Fra-2 and c-Myb were consistently co-expressed in cutaneous T-cell lymphomas (CTCLs), and contributed to cell proliferation. Furthermore, we showed that c-Myb was a direct target gene of Fra-2 in CTCLs. In addition, we identified that RASGRP2 was a c-Myb target gene and contributed to cell proliferation in CTCLs. Taken together, our findings support the notion that the Fra-2-c-Myb oncogenic pathway plays a major role in the oncogenesis of CTCLs.
|
Research Products
(1 results)
