2010 Fiscal Year Final Research Report
Pharmacogenomics of biological markers related with antipsychotic-related QT prolongation
| Project/Area Number |
21791117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
FUKUI Naoki Niigata University, 医歯学系, 助教 (90535163)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 抗精神病薬 / 24時間ホルター心電図 / QT延長 / 薬理ゲノム学 |
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| Research Abstract |
Most antipsychotic agents can cause QT prolongation, which causes torsades de pointes. This study investigated the circadian dynamics of the QT interval in patients treated with antipsychotics and healthy controls, using 24-h Holter electrocardiogram (ECG) in a clinical setting. (Result (1)) We investigated the QT intervals between risperidone, olanzapine and control group. The mean nighttime QTcF of the risperidone group was significantly longer than that of the olanzapine and control groups. (Result (2)) We investigated the association between QT intervals and gene polymorphisms related with QT prolongation (NOS1AP, SCA5A, KCNQ1, KCNJ2, PLN, LITAF) in patients treated with antipsychotics. We observed the increase of QT interval in individuals having more number of QT-prolonging allele.
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[Journal Article] Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures.2010
Author(s)
Takahashi M, Hayashi H, Watanabe Y, Sawamura K, Fukui N, Watanabe J, Kitajima T, Yamanouchi Y, Iwata N, Mizukami K, Hori T, Shimoda K, Ujike H, Ozaki N, Iijima K, Takemura K, Aoshima H, Someya T
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Journal Title
Schizophr Res 119(1-3)
Pages: 210-218
Peer Reviewed
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[Remarks] ホームページ等
